diff --git a/package/gobject-introspection/Config.in b/package/gobject-introspection/Config.in
index 7b47c9561e..54a33d8666 100644
--- a/package/gobject-introspection/Config.in
+++ b/package/gobject-introspection/Config.in
@@ -19,7 +19,7 @@ config BR2_PACKAGE_GOBJECT_INTROSPECTION
 	# can be verified.
 	depends on BR2_TOOLCHAIN_GCC_AT_LEAST_4_9
 	depends on BR2_HOST_GCC_AT_LEAST_8 # host-qemu
-	depends on BR2_TOOLCHAIN_USES_GLIBC
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL
 	# gobject-introspection does not require python3 to run on the
 	# target; however, because the tools run in a qemu wrapper, a
 	# cross-compiled python3 must be installed to staging. As there
@@ -48,9 +48,9 @@ comment "gobject-introspection needs python3"
 	depends on !BR2_PACKAGE_PYTHON3
 	depends on BR2_PACKAGE_GOBJECT_INTROSPECTION_ARCH_SUPPORTS
 
-comment "gobject-introspection needs a glibc toolchain, gcc >= 4.9, host gcc >= 8"
+comment "gobject-introspection needs a glibc or musl toolchain, gcc >= 4.9, host gcc >= 8"
 	depends on BR2_USE_MMU
 	depends on BR2_PACKAGE_GOBJECT_INTROSPECTION_ARCH_SUPPORTS
-	depends on !BR2_TOOLCHAIN_USES_GLIBC || \
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL) || \
 		!BR2_TOOLCHAIN_GCC_AT_LEAST_4_9 || \
 		!BR2_HOST_GCC_AT_LEAST_8