diff --git a/package/python3/python3.mk b/package/python3/python3.mk
index 012a46edcb..ef0658262a 100644
--- a/package/python3/python3.mk
+++ b/package/python3/python3.mk
@@ -189,6 +189,15 @@ else
 PYTHON3_CONF_ENV += ac_cv_big_endian_double=yes
 endif
 
+PYTHON3_CFLAGS = $(TARGET_CFLAGS)
+
+ifeq ($(BR2_TOOLCHAIN_HAS_GCC_BUG_121567),y)
+PYTHON3_CFLAGS += -O1
+endif
+
+PYTHON3_CONF_ENV += \
+	CFLAGS="$(PYTHON3_CFLAGS)"
+
 ifeq ($(BR2_PACKAGE_GETTEXT_PROVIDES_LIBINTL),y)
 PYTHON3_DEPENDENCIES += gettext
 endif